CambiaLabs IP – β-Glucuronidase (GUS) and Glucuronide Permease Gene System
The invention relates to the β-glucuronidase (GUS) gene fusion system, and to the cloning and characterisation of the β-glucuronidase and glucuronide permease genes of Escherichia coli. Because of the abundance and availability of useful substrates for β-glucuronidase enzyme, GUS gene fusions may serve as a superior reporter gene system as well as an effective means of altering cellular phenotype. There are also implementations in conjunction with recombinant glucuronide permease (see below), which may be used to render host cells permeable to β-glucuronidase substrates. Issued in the United States as Patent Numbers 5,268,463, 5,432,081 and 5,599,670.
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