What is available in this project?
hTERT encodes the protein component of human telomerase, an enzyme that is important in cell division, cell aging and cell proliferation control (implicated in cancer and stem cell research), as described in Kilian et al. (1997) “Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types”, Human Molecular Genetics, 6: 2011-2019. This gene and its splice variants were isolated and described in work at CAMBIA funded by the Monticello Group using materials from the Peter MacCallum Cancer Centre.
Licenses for the following patents and patent applications for Vertebrate Telomerase and Uses Thereof are available to all who agree to the terms of a BiOS license (see below): US Patent 6,916,642, US Patent 6,846,662, US published application 2005/176022, Australia 748,442, NZ 501,962, Brasil P19810643-0, Canada 2,294,792, China 98808383.3, EP 04026579.5, HK 01101501.9, Israel 133830, Japan 11-508771, Korean Patent 581990, Mexico 000196, and WO 1999/001560.
- Review article Hanahan, D.; Weinberg, R.A. Cell, Volume 100, Issue 1, 1 January 2000, Pages 57-70, “The Hallmarks of Cancer“
- Technology Landscape on CAMBIA Patent Lens: Human Telomerase Gene