Patent owned by the University of British Columbia
A team lead by Dr Edward P. Candido at the Department of Biochemistry, University of British Columbia conducted research on stress response using Caenorhabditis elegans as a model organism. Major research interests of Dr Candido’s laboratory include the ubiquitin-conjugation system and heat shock protein (hsp) biology, one study of which concerned the creation of transgenic C. elegans having the promoter of hsp fused to the lacZ gene of E. coli that was evaluated for the potential to be used as a biosensor to detect environmental pollutants. The following three related scientific articles were published by the research team:
- Stringham et al. (1992). Temporal and spatial expression patterns of the small heat shock (hsp16) genes in transgenic Caenorhabditis elegans. Mol Biol Cell. 3(2):221-33.
- Stringham and Candido (1993). Transgenic strains of the nematode Caenorhabditis elegans as biological monitors of environmental stress. FASEB J. 7(7): A1222-A1222.
- Stringham and Candido (1994). Transgenic hsp16-lacZ strains of the soil nematode Caenorhabditis elegans as biological monitors of environmental stress. Environ Toxicol Chem. 13(8): 1211-1220.
Details of the patent document
|Patent or Publication no.||Title, Independent Claims and Summary||Assignee and licensing information|
||Title – Biological systems incorporating stress-inducible genes and reporter constructs for environmental biomonitoring and toxicology
The claims are generally drawn towards:
Definitions extracted from the description are:
Granted US 5877398 has expired due to non-payment of maintenance fees.
Although not recited in the claims (and therefore are not enforceable), the specification provides other possible reporter systems by potentially using a bacterial or firefly luciferase gene as the reporter gene, and other promoters that ‘respond to different classes of stressors or conditions…, e.g. metallothionein or cytochrome P450 promoters, or other heat shock promoters’.
|University of British Columbia
University-Industry Liaison Office
The University of British Columbia
|Date of search||28 Apr 2006|
|Database searched||Patent Lens|
|Type of search||Simple|
|Collections searched||AU-B, US-A, US-B, EP-B, WO|
|Search terms||biomonitor and cadmium|
|Comments||Of the 22 results identified using these search terms, 3 results were identified as being of particular interest based on their abstracts and a review of their claims.|