A word or two about nomenclature
“Telomerase” is used in this landscape paper to mean the catalytic subunit (i.e., protein with enzymatic activity) of the telomerase complex. Some use the term “telomerase” to mean the whole ribonucleoprotein complex, of which the enzyme is but one component. Thus, when reading articles or patents about telomerase, the reader is cautioned to confirm how the term is used in the context of the document.
Furthermore, in early papers and patent applications, the human protein and gene name of the catalytic subunit was variously designated as hTRT, hEST2, and hTCS1. While hTRT is still sometimes seen, the consensus term is hTERT. In this report, hTERT is used regardless of the nomenclature in the original document.