Wild-type telomerase

This section presents patents that claim aspects of nucleic acid sequences encoding wild-type[1] telomerase.  What is “wild-type” telomerase?  For this landscape analysis it is defined as the catalytic protein containing 1132 amino acids in human and homologues in other species.  This definition, prevalent in scientific literature and in patents, has been arrived at somewhat arbitrarily.  It came about from the first publications describing the cloning of human telomerase (Meyerson et al. 1997e; Nakamura et al. 1997) in which two sequences of telomerase were found, but only one of which had an open reading frame encoding the known motifs of telomerase.

[1] In some publications, the term “reference telomerase” is used synonymously with “wild-type telomerase”.