A bar gene in combination with a virus resistance gene

This group of patents covers the combination of virus resistance genes and herbicide resistance genes in one single transgenic plant. Having one or the other is already a valuable asset in agriculture. Having both has the potential of adding significant value to crops, as weed control and viruses are two major problems in crop management. Use of this invention, however, by the assignees or licensees might still require separate negotiations with owners of patents on virus resistance genes or methods to obtain transgenic virus resistant plants.

Assigned to Hoechst Schering AgrEvo GmbH
(now part of the Bayer Crop Science)
EP 513054 B1 21 Apr 1999 Plant cells containing a combination of a phosphinothricin and a virus resistance gene. A process to generate plants with improved agronomic characteristics from these cells.
EP 899340 A2 3 Mar 1999
(publ. date)
Plants, plant cells or parts, and seed containing a gene construct combining virus and herbicide resistance. A preferred embodiment contains a phosphinothricin resistance gene from Streptomyces sp.
EP 714237 B1 4 Nov 1998 A method to increase yield (not necessarily through weed control) by treating plants resistant to glutamine synthetase inhibitors —transgenic or not— with inhibitors such as glufosinate.
US 5633434 27 May 1997 A DNA construct combining a bar gene and a virus resistance gene. Plant cells expressing the construct. A method to improve growth by treating plants expressing the construct with phosphinothricin.
US 5792926 11 Aug 1998 Plants and plant cells transformed with a construct comprising a phosphinothricin resistance gene and a viral coat protein capable of conferring virus resistance to the plant.
US 5908810 1 Jun 1999 A method to improve crop yield by treating transgenic plants resistant to a glutamine synthetase inhibitor with an inhibitor such as phosphinothricin —in case the resistance is conferred by the bar gene.
US 5739082 14 Apr 1998 A method to improve growth of crops by treating plants resistant to glutamine synthetase inhibitors with a stimulating amount of an inhibitor such as phosphinothricin —in case the resistance is conferred by the bar gene.
Related Patents Granted patents in : Austria AT 172847 E; Australia AU 654662 B2; AU 700325 B2; China CN 1089555 B; Czech Rep CZ 286623 B6; Germany DE 59109123 C0; DE 59407241; Hungary HU 219059 B; HU 220775 B1; OAPI OA 9664 A; Poland PL 180005 B1; Romania RU 2166850 C2.
Applications in : Canada CA 2,075,209 AA, CA 2,169,282 AA, Germany DE 4003045 A1, DE 4327056 A1, Denmark DK 714237 T3, Spain ES 2131050 T3, ES 2124906 T3, Hungary HU 64395 A2, JP 5506568 T2, Japan JP 9501179 T2, New Zealand NZ 236979 A, NZ 271372 A, South Africa ZA 9406038 A

The number of related patents suggests that this invention represents a high value to the assignee. The combination of two agronomically important genes in one invention — a virus resistance gene and a herbicide resistance gene — increases the commercial options of a transgenic crop.

Beside the obvious use of a herbicide to eliminate weeds the inventors claim improved growth of crops after application. Dependent claims in this patent family mention phosphinothricin as the herbicide of choice.