Patents on Yeast Copper-Responsive Promoter
Genentech has a granted United States patent related to inducible transcription control sequences isolated from a yeast metallothionein gene. These transcriptional control sequences are also known as yeast copper chelatin promoter.
The transcriptional control sequences of the invention include the transcriptional promoter and the metal ion regulatory region. As well, in a vector to be replicated in suitable host, a desired gene is under the control of a yeast chelatin promoter, a yeast chelatin transcriptional control sequence, or a metal ion regulatory region from yeast chelatin.
The yeast chelatin transcriptional control sequence contains the chelatin promoter, including transcription initiation and ribosome binding sites. This is a useful promoter in its own right, but to be induced by metal ions, the metal ion regulatory region is needed. This last region is also useful when ligated to other, non-metallothionein promoters, which are recognized by the desired host.
An isolated DNA sequence of a yeast chelatin metal ion regulatory region is also part of the protected invention.
Patent Number | Title, Independent Claims and Summary of Claims | Assignee | ||
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US 4940661
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Title – Metallothionein transcription control sequences and use thereof
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Genentech Inc. |
Note: Patent information was last updated on 19 May 2006. Search terms: “Metallothionein” in abstract and “Genentech” in applicant. Patent database: PatentLens.
Patent on a mouse metallothionein promoter
The granted United States patent of University Patents Inc. (now Competitive Technologies Inc.) relates to the metal-responsive promoter/regulator sequences of the mouse metallothionein-I gene.
The mouse metallothionein-I gene promoter of the invention is operatively linked to a DNA sequence of interest, which is expressed in response to variations in the concentration of metal ions in the environment. The host organism, which stably incorporates the DNA sequence of interest, is a mammalian host cell.
Patent Number | Title, Independent Claims and Summary of Claims | Assignee | |||
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US 4579821
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Title – Control of DNA sequence transcription
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University Patents Inc. (now Competitive Technologies) |
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Remarks |
The related granted European patent EP 94428 lapsed in all European contracting states. Related application filed in Japan (JP 7083715 B4). |
Note: Patent information was last updated on 19 May 2006. Search terms: “transcription” in abstract and “University patents” in applicant. Patent database: PatentLens in combination with INPADOC.
Patent on a human metallothionein promoter
The mammalian metallothionein promoter system claimed by the University of California (Berkeley) in a granted United States patent relates to a human metallothionein IItranscriptional regulatory system, which allows for regulated control of expression by heavy metals and glucocorticoids.
Patent Number | Title, Independent Claims and Summary of Claims | Assignee | |||
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US 4601978
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Title – Mammalian metallothionein promoter system
The claimed invention is drawn to:
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University of California (Berkeley) |
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Remarks |
Another United states patent titled ” High efficiency eukaryotic metallothionein promoter system” (US 4511652) also expired. |
Note: Patent information was last updated on 19 May 2006. Search terms: “metallothionein” in abstract and “University of California” in applicant. Patent database: PatentLens.