Promoters based on estrogen receptor (ER)
The Rockefeller University has three granted patents in the United States and one granted patent in Australia directed to methods for transforming plant cells with a vector comprising a regulatory region from an ER. It also filed two European patent applications and one Canadian patent application.
Specific Patent Information
Patent Number |
Title, Independent Claims and Summary of Claims |
Assignee | |||||||||||||
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US 6063985
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Title – Chemical inducible promoter used to obtain transgenic plants with a silent marker
Independent claim 1 is drawn to: A method for selecting transgenic plants comprising a silent selectable marker by transforming a plant cell with a vector comprising a silent selectable marker, selecting the plant cell in the presence of an inducer and excising shoots for generating trasgenic plants in the absence of the inducer. The silent selectable marker gene (an ipt gene, a CKI1 gene or a gene from the knotted family) is under the control of an inducible promoter which can be turned on by applying steroid (one such promoter is based on the glucocorticoid receptor as claimed in the dependent claims). |
The Rockefeller University |
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US 6784340
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Title – Chemical inducible promoter used to obtain transgenic plants with a silent marker
This patent is a Continuation in part of US 6063985.
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US 6452068
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Title – Chemical inducible promoter used to obtain transgenic plants with a silent marker
This patent is a Continuation in part of US 6063985.
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EP 1232273 A2
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Title – Chemical inducible promoters used to obtain transgenic plants with a silent marker
European application EP 1 232 273 A2 claims methods for selecting transgenic plants by inserting a vector having a gene of interest under the control of an ER. When an inducer compound is added, the transformed plants express the gene of interest. The genes under the control of the inducible promoter are:
The compounds 17-beta-estradiol and 4-hydroxyl tamoxifen are cited as inducers of the transcription system. Although the title of the application reads chimeric promoters, these are not subject matter of the independent claims as filed. (??- It doesn’t according to this table) However, some dependent claims mention the use however of the DNA-binding domain of the bacterial repressorLexA assembled with the regulatory domain of the ER. |
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Remarks |
An United States application (US 2003/150013 A1) , as a Division of US 6452068, and a Canadian application (CA 2391003) are pending. | ||||||||||||||
EP 1242604 A2
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Title – Chemical inducible promoters used to obtain transgenic plants with a silent marker and organisms and cells and methods of using same for screening for mutations
The claims range those drawn to organisms or cells comprising a transgenic inducible promoter to a specific chimeric inducible promoter corresponding to the XVE promoter mentioned above in “scientific aspects” and to lettuce plants transformed with an inducible promoter driving particular genes promoting shoot development and antibiotic resistance. The broadest claims originally filed recite:
In other claims, the chimeric inducible promoter comprises:
In addition, the claims recite either a transgenic plant cell or specifically a transgenic lettuce plant comprising an inducible promoter, which in some cases explicitly comprises an ER. The same genes disclosed in EP 1282273 A2 under the control of the inducible promoter are in the claims as filed, with the exception of genes promoting somatic embryogenesis. |
The Rockefeller University |
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AU 782958 B2
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Title – Chemical inducible promoters used to obtain transgenic plants with a silent marker and organisms and cells and methods of using same for screening for mutations
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Note: Patent information on this page was last updated on 22 March 2006.