Patents granted to Cornell
The patents disclose a vector (BiBAC) based on a bacterial artificial chromosome (BAC) and designed for Agrobacterium -mediated plant transformation.
The patents disclose that:
- heterologous DNA cloned into the vector can be maintained in E. coli as a single copy,
- the vectors can be transferred from E. coli to Agrobacterium (e.g., by triparental mating or by isolation from E. coli and electroporation into Agrobacterium), and
- Agrobacterium used for plant transformation contains the BiBAC vector having a heterologous gene and a helper plasmid to facilitate the transfer of the foreign gene into the plant (a binary vector system).
Specific Patent Information
Patent Number | Title, Independent Claims and Summary of Claims | Assignee | |
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US 5733744
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Title – Binary BAC vector
The United States patent US 5733744 claims elements of a vector for transferring heterologous DNA into a plant. The elements are:
The patent discloses that “maintenance as a single copy refers to a non-replicating cell, i.e. a cell not undergoing cell division; during cell division, the copy per cell increases to nearly two complete copies per cell. It’s not clear whether an “Agrobacterium T-border sequence” is one which must be found naturally in Agrobacterium. The disclosure describes cloned sequences that were so derived. A reading of the file history might be instructive. |
Cornell |
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US 5977439
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Title – Binary BAC vector
Methods for transforming a plant with the vector and obtaining transformed plants are claimed in the United States patent 5 977 439. |
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EP 805851 B1
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Title – Binary BAC vector
Designated contracting States at the time of grant are: Austria (patent ceased as reported by EPO), Belgium (patent lapsed as reported by EPO), Switzerland (patent ceased as reported by INPADOC), Germany, Denmark (patent lapsed as reported by EPO), Spain (patent lapsed as reported by EPO), France, United Kingdom, Greece (patent lapsed as reported by EPO), Ireland (patent lapsed as reported by INPADOC), Italy, Liechtenstein (patent lapsed as reported by INPADOC), Luxembourg, Monaco (patent lapsed as reported by EPO), Netherlands (patent lapsed as reported by INPADOC), Portugal, Sweden (patent lapsed as reported by INPADOC). |
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EP 805851 A1
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Title – Binary BAC vector
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Remarks | National phase entry of WO 1996/21725 in Japan (JP H11/500306) is pending. |
Note: Patent information on this page was last updated on 24 February 2006.